Careers

Lead The Way In Gene Therapy With AskBio


AskBio was founded by gene therapy industry leaders, whose discoveries and AAV platform technology and applications form the foundation for how important gene therapies are effectively and safely delivered to millions of people who suffer from incurable conditions. One of AskBio’s founders, Dr. Jude Samulski, is considered the father of AAV gene therapy and is the inventor of over 280 patents and applications for AAV technology.

Today, AskBio is leading the way in gene therapy and we need exceptional researchers, scientists, analysts and clinicians to join us in our quest to change lives with groundbreaking gene therapies and manufacturing processes. When you join the AskBio team:

  • You’ll be part of one of the most exciting gene therapy research and delivery companies in the world
  • Your work will contribute to the advancement of therapies and applications that are revolutionizing curable possibilities
  • You will have opportunities for significant growth with competitive pay and outstanding benefits
  • You will be a part of a collaborative culture that shares a genuine desire and belief to change the world

Driven To Bring Cures To Millions Across The World

AskBio and its gene therapy technology based on the discoveries of Dr. Jude Samulski drive the work of more than two-thirds of gene therapy companies worldwide. Dr. Samulski was the first to clone AAV which was the dawning of hope for millions suffering from devastating diseases.

Open Positions

Please review the following open positions and apply now to upload your resume.

  • Analytical Scientist

    The purpose of the Analytical Scientist position is to provide the planning, development, qualification and execution of analytical assays to support internal Research & Development, Process Development and non- clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides bioanalytical test methods development, qualification and validation.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Analytical Scientist to join the AskBio team!

    About the role: 

    The Analytical Scientist will provide analytical testing support for R&D and Process Development teams to assist in the development and analytical characterization of new capsids, therapeutic cassettes and improved manufacturing process steps.

    Responsibilities and Accountabilities

    • Develop and optimize bioanalytical test methods for rAAV gene therapy products intended for non-clinical and clinical applications.
    • Work closely with our partners for qualification and validation of analytical methods.
    • Author development reports, study protocols, SOPs and pre-validation reports.
    • Evaluating CRO/CMO test results and writing summary reports of the results when needed.
    • Identify basic technical issues, out-of-specifications results, instrument malfunctions and methodology problems, and participate in investigations.
    • Develop strategies to transfer these methods when needed to our partners or collaborators.
    • Detailed, organized, formal record keeping through lab notebooks.

    About you: 

    MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at
    least 1-3 years’ experience.

    Demonstrated experience in analytical techniques such as: PCR, sequencing, qPCR, SDSPAGE, HPLC, ddPCR, cell-based assays, ELISA, SEC, etc.

    Experience with mammalian cell culture techniques.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required in addition excellent interpersonal skill.

    Ability to multitask among multiple projects and teams and work independently in a fast paced, highly interactive environment.

    Demonstrated independence in experimental design, execution, data analysis, statistical analysis and troubleshooting are required.

    Attention to detail with excellent organizational and record keeping skills is a requirement.

    Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About you: 

    Knowledge of or direct experience with rAAV vectors is a plus.

    Knowledge of FDA and EMA cGMP industry standards for analytical development and method validation a plus.

    Experience with writing regulatory documents or working in cGMP USP/EP environments would be considered a plus.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Associate Scientist Downstream Process Development

    The Associate Scientist- Downstream Process Development position provides support for execution of experiments designed to optimize recombinant adeno-associated virus downstream processing and purification for gene therapy applications. This role requires knowledge and a desire to learn principles of chemical engineering, biology, biochemistry, and related chemistries, preferably in chromatography, centrifugation and filtration design principles.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Associate Scientist Downstream Process Development to join the AskBio team!

    About the role: 

    The Associate Scientist- Downstream Process Development position provides support for execution of experiments designed to optimize recombinant adeno-associated virus downstream processing and purification for gene therapy applications. This role requires knowledge and a desire to learn principles of chemical engineering, biology, biochemistry, and related chemistries, preferably in chromatography, centrifugation and filtration design principles.

    Responsibilities and Accountabilities

    • Assist in the development of robust, efficient, scalable purification strategies for improving downstream process performance in collaboration with fellow scientists, collaborators, and upper management.
    • Communicate and collaborate across functional areas such as upstream process development, analytical development, manufacturing and R&D.
    • Conduct experiments and analyses as part of a variety of research and development activities, e.g., small-scale studies, scale up studies, technology transfer and process development.
    • Evaluate and summarize the experimental results, develop and test hypotheses to improve understanding of downstream purification strategies, yield, purity, and recovery.
    • Prepare internally reviewed technical reports.
    • Provide team support through preparation of solutions, lab cleanliness, and maintaining inventory or necessary supplies.

    About you: 

    BS or MS degree in a biological or engineering discipline (Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent).

    Experience in laboratory research, and a desire to continue in a laboratory-focused roll.

    Minimum 1-3 years of experience in laboratory research required, preferably in recombinant protein/biomolecule purification development, technology transfer and/or bioprocess manufacturing.

    Experience with filtration and chromatography.

    A good understanding of protein chemistry, protein analytics, and bioprocess technology is required.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

    More About you: 

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Sound understanding of statistical experimental design and analysis such as design of experiments is a plus.

    Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus.

    Experience with global teams, especially Spanish speaking, a plus.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Molecular Biology Scientist

    The purpose of the Molecular Biology Scientist position is to provide the execution of molecular biology techniques for the generation of novel Adeno-associated virus capsids in addition to recombinant therapeutic genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report the results to colleagues.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Molecular Biology Scientist to join the AskBio team!

    About the role: 

    The purpose of the Molecular Biology Scientist position is to provide the execution of molecular biology techniques for the generation of novel Adeno-associated virus capsids in addition to recombinant therapeutic genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report the results to colleagues.

    Responsibilities and Accountabilities

    • Provide leadership role in building and optimizing the design of AAV gene therapy constructs.
    • Responsible for hands-on experimental design, execution, data analysis and reports for AAV vector core pipeline research and development programs.
    • Develop molecular assays to characterize AAV genome integrity, identity, vector variants, residual DNA quantification, as well as in-vitro potency to support product development and manufacturing of gene therapy products.
    • Identification and implementation of operational improvements and novel technologies to improve AAV vector expression and key quality attributes.
    • Participate in project related teams and other internal/external collaborations.
    • Prepare and review technical reports and SOPs to support CMC regulatory activities.
    • In collaboration with Gene Therapy Technical Operations Leadership, develop strategic and operational vision for the organization.
    • Select, develop, and evaluate personnel to ensure the efficient operation of the function and represent the department internally/externally.
    • Work seamlessly with cross functional stakeholders including Process Development, Analytical Development and Translational Research to help advance the AAV vector production portfolio.
    • Ensure the development of robust, well-characterized, high quality and high yielding vector expression system.
    • Ensure that scientific and technical challenges are resolved in a timely manner.
    • Contribute to budget and goal planning.
    • Contribute to a safe, efficient and effective environment with personal accountability.

    About you: 

    BS, MS, or PhD in Molecular and Cell Biology or related field.
    0-2 years of relevant experience with PhD.

    3-5 years of relevant experience with MS.

    5-10 years of relevant experience with BS.

    Knowledge of cGMP.

    Experience working in a laboratory setting.

    Knowledge of LIMS.

    Ability to work both independently and in a fast-paced team-oriented setting.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

    More About you: 

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Senior Scientist – Upstream Process Development Group Leader

    The purpose of the Senior Scientist Upstream Process Development Group Leader will lead the developing upstream (cell culture) processes for recombinant Adeno-associated viral (rAAV) vector gene therapies. This position manages and mentors a team of Associates and Scientists on upstream process development, scale-up, optimization, characterization, and transfer of projects while providing scientific expertise, guidance, and development opportunities.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Senior Scientist Upstream Process Development Group Leader to join the AskBio team!

    About the role: 

    The purpose of the Senior Scientist Upstream Process Development Group Leader will lead the developing upstream (cell culture) processes for recombinant Adeno-associated viral (rAAV) vector gene therapies. This position manages and mentors a team of Associates and Scientists on upstream process development, scale-up, optimization, characterization, and transfer of projects while providing scientific expertise, guidance, and development opportunities.

    Responsibilities and Accountabilities

    • Demonstrates innovative design, development, and execution of process development projects through literature review and scientific teamwork.
    • Assess and interpret experimental data using DOE and statistical techniques.
    • Develops robust, scalable, transferable processes for upstream production of rAAV clinical gene therapy vectors.
    • Serve as a Subject Matter Expert (SME) for the development of robust, high performing upstream processes with emphasis on transferability to cGMP manufacturing and supports regulatory filings.
    • Leads both from the bench and from the desk (designing studies, analyzing data, preparing reports and documents).
    • Training new or current team members and delegating tasks appropriately.
    • Provide input on the acquisition of capital equipment.
    • Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience.
    • Writes study reports, process characterization reports, transfer documents, and regulatory documents.
    • Authors manuscripts and presents results at scientific meetings.
    • Builds a culture that embraces continuous learning, innovation while encouraging team members to expand their technical skills and deepen their gene therapy expertise.

    About you: 

    MS or PhD (Chemical engineering, Bioengineering, Biology, Biochemistry, Virology, or related field) with 5+ years’ experience or MS with 8+ years’ experience, in process development of large molecule or cellular therapies.

    Knowledge and experience with media development, fed-batch, perfusion etc methodologies.

    Knowledge and working experience with cell culture process development in mammalian cells, process scale-up, bioreactor design and optimization, and transfection.

    Knowledge and experience with process characterization and transfer is essential. Expertise in DOE and statistical analysis of data is essential.

    Knowledge and experience with ambr systems.

    Knowledge of viral gene therapy (AAV vectors preferred); background in protein and/or viral engineering
    Experience leading teams of scientists and associate scientists.

    Understanding and knowledge of regulatory requirements for biologic products.

    Strong organizational, analytical and problem-solving skills.

    Demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings and collaborative interactions.

    Responsible for maintaining up-to-date knowledge of regulatory requirements and quality standards related to area of development.

    Responsible for maintaining up-to-date knowledge of regulatory requirements and quality standards related to area of development.

    Ability to work both independently and in a fast-paced team-oriented setting.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

    More About you: 

    Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.

    Experience in regulatory IND filing and working knowledge of US/EU CLD requirements is highly desirable.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Cell Line Engineering Scientist

    The Cell Line Engineering Scientist will be to investigate cellular and molecular mechanisms for optimal recombinant Adeno-associated virus vector production. This position offers the opportunity to impact a growing portfolio of gene therapy programs in a fast-paced and innovative research environment.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Cell Line Engineering Scientist to join the AskBio team!

    About the role: 

    The Cell Line Engineering Scientist will be to investigate cellular and molecular mechanisms for optimal recombinant Adeno-associated virus vector production. This position offers the opportunity to impact a growing portfolio of gene therapy programs in a fast-paced and innovative research environment.

    Responsibilities and Accountabilities

    • Lead, design and execute cell line development, clone screening, selection and stability determination for rAAV producer/stable cell lines.
    • Design and develop novel ways of integrating and controlling gene expression of viral genes in stable cell lines.
    • Support early stage discovery efforts for lead candidate identification.
    • Implement high throughput and cutting-edge cell line development technologies to optimize platforms and shorten cycle time.
    • Train and manage team members and delegating tasks appropriately.
    • Provide input on the acquisition of capital equipment.
    • Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience.
    • Maintain a current awareness of scientific literature and actively applies new concepts and technologies as appropriate.

    About you: 

    MS or Ph.D. in Biological Sciences specializing in Cell Biology, Molecular Biology, Biochemistry, Virology, Chemical engineering or Biomedical Engineering with a minimum of 5-7 years’ experience in an industrial/research laboratory developing mammalian cell lines.

    MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 1-3 years’ experience.

    Excellent aseptic skills, experience with vector engineering, high-throughput gene expression technology and cell line engineering is a must.

    Experience in developing novel molecular and analytical tools for use during cell line development is a must.

    Proficient in a broad range of cell and molecular biology techniques including cloning (eg. Gibson and Golden Gate Assembly) and gene editing technologies such as CRISPR/Cas9.

    In-depth knowledge and extensive hands-on experience in mammalian cell line engineering using gene editing/KD approaches (CRISPR, Meganuclease and si/shRNA). Experience with CRISPR knock-in is strongly preferred.

    Experience with cell characterization technologies including GRO_Seq, DNA_Seq, qPCR, Western blot, ELISA, etc.

    Hands on experience with FAC-Sorting and Flow cytometry assay development.  Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required in addition excellent interpersonal skill.

    More About you: 

    Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.

    Experience in regulatory IND filing and working knowledge of US/EU CLD requirements is highly desirable.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Senior Associate Scientist – Protein Engineer

    The purpose of the Senior Associate Scientist Protein Engineer is to provide the execution of Protein analysis and characterization of novel Adeno-associated Virus capsids in addition to recombinant therapeutics genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report results to colleagues

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Senior Associate Scientist Protein Engineer to join the AskBio team!

    About the role: 

    The purpose of the Senior Associate Scientist Protein Engineer is to provide the execution of Protein analysis and characterization of novel Adeno-associated Virus capsids in addition to recombinant therapeutics genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report results to colleagues.

    Responsibilities and Accountabilities

    • Design protein assays to solve complex questions and provide analysis on said assays.
    • Perform ELISA, IHC, Western blot, Immunofluorescence, and Immunoprecipitation.
    • Perform molecular biology techniques (Gibson Cloning, PCR, RT-PCR, qPCR, Restriction enzyme analysis, and preparing DNA libraries).
    • Design of cloning strategies for plasmid vector construction.
    • Tissue Culture of Non-adherent and adherent cells.
    • Transfections including liposome-mediated, electroporation and viral.
    • In vitro transcription/translation-based protein expression and small-scale purification.
    • Communication of work, plans and progress using written and verbal communication in small groups and large meetings.

    About you: 

    B.S, degree in Microbiology, Molecular Biology, Cell Biology, Biology or related field.

    3-5 years of industry experience or equivalence based on level of degree completion.

    Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required in addition excellent interpersonal skill.

    More About you: 

    Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.

    Experience with global teams, especially Spanish speaking, a plus.

    Must possess strong workload planning skills, organization, attention to detail, and follow through.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    Must be self-motivated, organized, capable of working independently as well as in a collaborative/group environment to collaborate with manufacturing process development staff on experimental studies.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?