Careers

Lead The Way In Gene Therapy With AskBio


AskBio was founded by gene therapy industry leaders, whose discoveries and AAV platform technology and applications form the foundation for how important gene therapies are effectively and safely delivered to millions of people who suffer from incurable conditions. One of AskBio’s founders, Dr. Jude Samulski, is considered the father of AAV gene therapy and is the inventor of over 280 patents and applications for AAV technology.

Today, AskBio is leading the way in gene therapy and we need exceptional researchers, scientists, analysts and clinicians to join us in our quest to change lives with groundbreaking gene therapies and manufacturing processes. When you join the AskBio team:

  • You’ll be part of one of the most exciting gene therapy research and delivery companies in the world
  • Your work will contribute to the advancement of therapies and applications that are revolutionizing curable possibilities
  • You will have opportunities for significant growth with competitive pay and outstanding benefits
  • You will be a part of a collaborative culture that shares a genuine desire and belief to change the world

Driven To Bring Cures To Millions Across The World

AskBio and its gene therapy technology based on the discoveries of Dr. Jude Samulski drive the work of more than two-thirds of gene therapy companies worldwide. Dr. Samulski was the first to clone AAV which was the dawning of hope for millions suffering from devastating diseases.

Open Positions

Please review the following open positions and apply now to upload your resume.

  • Scientist – Molecular Biology

    The purpose of the Molecular Biology Scientist position is to provide the execution of molecular biology techniques for the generation of novel Adeno-associated virus capsids in addition to recombinant therapeutic genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report the results to colleagues.

    1. Scope
    1.1 Department Name: Corporate Genetics Lab
    1.2 Reports To: Director Process Development

    2. Principal Responsibilities and Accountabilities
    2.1 Design of cloning strategies for plasmid vector construction
    2.2 Generation of DNA libraries
    2.3 DNA, RNA and protein isolation, purification and characterization
    2.4 Restriction enzyme digest analysis
    2.5 Sanger sequencing sample preparation
    2.6 PCR, RT-PCR, qPCR
    2.7 Analyze sequencing data using molecular biology software and create plasmid maps
    2.8 Western, Northern and Southern blots
    2.9 Mammalian cell culture techniques including transfection
    2.10 Bacterial cell cloning, freezing, and expansion
    2.11 Detailed, organized, formal record keeping through lab notebooks
    2.12 Communication of work, plans and progress using written and verbal communication in small and group settings.

    3. Specific Skills and Abilities
    3.1 Must be self-motivated, organized, capable of working independently as well as in a collaborative/group environment to collaborate with manufacturing process development staff on experimental studies
    3.2 Should possess strong oral and written communication skills
    3.3 Good judgment and innovation to achieve a solution within standard practices and
    procedures
    3.4 Strong analytical and computer skills are required.
    3.5 Sound understanding of statistical experimental design and analysis such as design of experiments is a plus
    3.6 Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus
    3.7 Experience with global teams, especially Spanish speaking, a plus

    4. Latitude
    4.1 This position requires the ability to act independently and to take initiative with minimal supervision
    4.2 This role has no spend authority except through request process

    5. Minimum Qualifications
    5.1 BS, MS, or PhD in Molecular and Cell Biology or related field
    5.2 0-2 years of relevant experience with PhD
    5.3 3-5 years of relevant experience with MS
    5.4 5-10 years of relevant experience with BS.
    5.5 Must have strong interpersonal, teamwork, and collaboration skills.
    5.6 Must possess strong workload planning skills, organization, attention to detail, and follow through.
    5.7 Must have excellent written and verbal communication skills. Ability to prioritize and multi-task concurrent project demands.
    5.8 Strong computer skills in Microsoft Office required e.g. Word, Excel, and PowerPoint.
    5.9 Must have a passport and ability to travel internationally

    6. Physical and Cognitive Demands
    6.1 Must be able to hear, see and speak
    6.2 Dexterity to manage presentations, work with equipment in demonstrations or advisement and to handle daily office equipment
    6.3 Must be able to move about the office and required company locations in diverse environments
    6.4 Must be able to maintain a high level of consistent cognitive function to negotiate complex transactions with clients and prospects
    6.5 Must be able to tolerate normal office climatic conditions associated with daily activities and if in travel to remote locations
    6.6 Must be able to physically travel to remote locations, including, but not limited to, international and remote locations.

  • Sr Scientist – Upstream PD Group Leader

    The Senior Scientist Group Leader will lead the developing upstream (cell culture) processes for recombinant Adeno-associated viral (rAAV) vector gene therapies. This position manages and mentors a team of Associates and Scientists on upstream process development, scale-up, optimization, characterization, and transfer of projects while providing scientific expertise, guidance, and development opportunities.

    1. Scope
    1.1 Department Name: Manufacturing-Process Development
    1.2 Reports To: Director of Process Development

    2. Principal Responsibilities and Accountabilities
    2.1 Demonstrates innovative design, development, and execution of process development projects through literature review and scientific teamwork.
    2.2 Assess and interpret experimental data using DOE and statistical techniques.
    2.3 Develops robust, scalable, transferable processes for upstream production of rAAV clinical gene therapy vectors.
    2.4 Serve as a Subject Matter Expert (SME) for the development of robust, high performing upstream processes with emphasis on transferability to cGMP manufacturing and supports regulatory filings.
    2.5 Leads both from the bench and from the desk (designing studies, analyzing data, preparing reports and documents).
    2.6 Training new or current team members and delegating tasks appropriately.
    2.7 Provide input on the acquisition of capital equipment
    2.8 Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience
    2.9 Writes study reports, process characterization reports, transfer documents, and regulatory documents.
    2.10 Authors manuscripts and presents results at scientific meetings
    2.11 Builds a culture that embraces continuous learning, innovation while encouraging team members to expand their technical skills and deepen their gene therapy expertise.

    3. Specific Skills and Abilities
    3.1 Ability to multi-task.
    3.2 Ability to work in a team-based environment
    3.3 Understanding and knowledge of key software programs
    3.4 Understanding and knowledge of regulatory requirements for biologic products
    3.5 Strong organizational, analytical and problem-solving skills
    3.6 Demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings and collaborative interactions
    3.7 Responsible for maintaining up-to-date knowledge of regulatory requirements and quality standards related to area of development.

    4. Latitude
    4.1 This position requires the ability to act independently and to take initiative with minimal supervision
    4.2 This role has no spend authority except through request process.

    5. Minimum Qualifications
    5.1 MS or PhD (Chemical engineering, Bioengineering, Biology, Biochemistry, Virology, or related field) with 5+ years experience or MS with 8+ years experience, in process development of large molecule or cellular therapies
    5.2 Knowledge and experience with media development, fed-batch, perfusion etc methodologies
    5.3 Knowledge and working experience with cell culture process development in mammalian cells, process scale-up, bioreactor design and optimization, and transfection
    5.4 Knowledge and experience with process characterization and transfer is essential. Expertise in DOE and statistical analysis of data is essential.
    5.5 Knowledge and experience with ambr systems
    5.6 Knowledge of viral gene therapy (AAV vectors preferred); background in protein and/or viral engineering
    5.7 Experience leading teams of scientists and associate scientists
    5.8 Successfully demonstrated ability to work independently manage a group
    5.9 Ability to multi-task.
    5.10 Ability to work in a team-based environment
    5.11 Understanding and knowledge of key software programs
    5.12 Understanding and knowledge of regulatory requirements for biologic products
    5.13 Strong organizational, analytical and problem-solving skills
    5.14 Demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings and collaborative interactions
    5.15 Responsible for maintaining up-to-date knowledge of regulatory requirements and quality standards related to area of development.

    6. Physical and Cognitive Demands
    6.1 Must be able to hear, see and speak
    6.2 Dexterity to manage presentations, work with equipment in demonstrations or advisement and to handle daily office equipment
    6.3 Must be able to move about the office, laboratories and required company locations in diverse environments
    6.4 Must be able to maintain a high level of consistent cognitive function to negotiate complex transactions with clients and prospects
    6.5 Must be able to tolerate normal office climatic conditions associated with daily activities and if in travel to remote locations
    Must be able to physically travel to remote locations, including, but not limited to, international and remote locations.

  • Senior/Scientist – DNA Manufacturing/Process Development Group Lead

    The Scientist position provides the planning and execution of plasmid manufacturing in addition to experiments designed to optimize plasmid and dbDNA production, purification and scalability. This role requires working knowledge of microbiology, molecular biology, biochemistry and related chemistries, preferably in chromatography, centrifugation and filtration design principles along with fermentation and DNA manufacturing.

    1. Scope
    1.1 Department Name: Manufacturing/Process Development
    1.2 Reports To: Director Process Development

    2. Principal Responsibilities and Accountabilities
    2.1 Ability to lead a group of scientists while being hands-on at the bench.
    2.2 Oversee day-to-day activities of the DNA development/manufacturing team including planning, mentoring, and providing direction, when required, to improve all functions of the lab
    2.3 Knowledgeable of current and new technologies with a priority of implementing the use of new technologies
    2.4 Experimental design and establishment of project timelines
    2.5 Support higher management in the establishment and tracking of yearly budgets
    2.6 Develop robust, efficient, scalable strategies for improving DNA manufacturing process performance in collaboration with fellow scientists, collaborators, and upper management
    2.7 Communicate and collaborate across functional areas such as upstream process development, analytical development, manufacturing, R&D, project management and Regulatory
    2.8 Conduct experiments and analyses as part of a variety of research and development activities, e.g., small-scale studies, scale up studies, technology transfer and process development
    2.9 Evaluate and summarize the experimental results, develop and test hypotheses to improve understanding of DNA manufacturing strategies, yield, purity, and recovery
    2.10 Support technology transfer internally and externally, manufacturing and quality by design
    2.11 Prepare internally reviewed technical reports, CMC documents, manuscripts and internal and external oral presentations

    3. Specific Skills and Abilities
    3.1 Applicants should be self-motivated, organized, capable of working independently as well as in a collaborative/group environment to collaborate with manufacturing staff on experimental studies and GMP manufacturing
    3.2 Applicant must have experience with team building as well as motivational and project management skills
    3.3 Experience with downstream process development specific is a plus
    3.4 The successful candidate will possess strong oral and written communication skills
    3.5 Good judgment and innovation to achieve a solution within standard practices and procedures
    3.6 Strong analytical and computer skills are required
    3.7 Sound understanding of statistical experimental design and analysis such as design of experiments is a plus
    3.8 Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus
    3.9 Experience with global teams, especially Spanish speaking, a plus

    4. Latitude
    4.1 This position requires the ability to act independently and to take initiative with minimal supervision
    4.2 This role has no spend authority except through request process

    5. Minimum Qualifications
    5.1 (MS or PhD degree in a biological or engineering discipline (Microbiology, Molecular Biology, Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent)
    5.2 Experience in laboratory research, and a desire to continue in a laboratory-focused roll
    5.3 Minimum 4-6 years of experience in laboratory research required, preferably in DNA manufacturing and development, technology transfer and/or bioprocess manufacturing
    5.4 Experience with fermentation, filtration and chromatography
    5.5 Familiarity with GLP and cGMP
    5.6 Strong academic record
    5.7 Demonstrated ability to generate results and innovative solutions with minimum supervision
    5.8 Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    6. Physical and Cognitive Demands
    6.1 Must be able to hear, see and speak
    6.2 Dexterity to manage presentations, work with equipment in demonstrations or advisement and to handle daily laboratory and office equipment
    6.3 Must be able to move about the office/laboratory and required company locations in diverse environments
    6.4 Must be able to maintain a high level of consistent cognitive function to negotiate complex transactions with clients and prospects
    6.5 Must be able to tolerate normal office climatic conditions associated with daily activities and if in travel to remote locations
    6.6 Must be able to physically travel to remote locations, including, but not limited to, international and remote locations.

  • Cell Line Engineering Scientist

    The primary role of the Cell Line Engineering Scientist will be to investigate cellular and molecular mechanisms for optimal recombinant Adeno-associated virus vector production. This position offers the opportunity to impact a growing portfolio of gene therapy programs in a fast-paced and innovative research environment.

    1. Scope
    1.1 Department Name: Research and Development
    1.2 Reports To: Chief Scientific Officer

    2. Principal Responsibilities and Accountabilities
    2.1 Lead, design and execute cell line development, clone screening, selection and stability determination for rAAV producer/stable cell lines
    2.2 Design and develop novel ways of integrating and controlling gene expression of viral genes in stable cell lines
    2.3 Support early stage discovery efforts for lead candidate identification
    2.4 Implement high throughput and cutting-edge cell line development technologies to optimize platforms and shorten cycle time
    2.5 Training new or current team members and delegating tasks appropriately
    2.6 Provide input on the acquisition of capital equipment
    2.7 Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience
    2.8 Maintain a current awareness of scientific literature and actively applies new concepts and technologies as appropriate
    2.9 Manage small team of direct reports

    3. Specific Skills and Abilities
    3.1 Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.
    3.2 Experience in regulatory IND filing and working knowledge of US/EU CLD requirements is highly desirable.
    3.3 Excellent analytical and problem-solving skills.
    3.4 Strong communication, documentation, time management and organizational skills.
    3.5 Proven ability to work independently, as well as to collaborate with peers and work effectively in a fast-paced team-oriented environment.
    3.6 Ability to successfully participate in a highly-creative and enthusiastic start-up environment.

    4. Latitude
    4.1 This position requires the ability to act independently and to take initiative with minimal supervision
    4.2 This role has no spend authority except through request

    5. Minimum Qualifications
    5.1. MS or Ph.D. in Biological Sciences specializing in Cell Biology, Molecular Biology, Biochemistry, Virology, Chemical engineering or Biomedical Engineering with a minimum of 5-7 years’ experience in an industrial/research laboratory developing mammalian cell lines.
    5.2 Excellent aseptic skills, experience with vector engineering, high-throughput gene expression technology and cell line engineering is a must.
    5.3 Experience in developing novel molecular and analytical tools for use during cell line development is a must.
    5.4 Proficient in a broad range of cell and molecular biology techniques including cloning (eg. Gibson and Golden Gate Assembly) and gene editing technologies such as CRISPR/Cas9.
    5.5 In-depth knowledge and extensive hands-on experience in mammalian cell line engineering using gene editing/KD approaches (CRISPR, Meganuclease and si/shRNA). Experience with CRISPR knock-in is strongly preferred.
    5.6 Experience with cell characterization technologies including GRO_Seq, DNA_Seq, qPCR, Western blot, ELISA, etc.
    5.7 Hands on experience with FAC-Sorting and Flow cytometry assay development. (Example) MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 1-3 years’ experience
    5.8 (Example) Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.
    5.9 (Example) Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    6. Physical and Cognitive Demands
    6.1 Must be able to hear, see and speak
    6.2 Dexterity to manage presentations, work with equipment in demonstrations or advisement and to handle daily office equipment
    6.3 Must be able to move about the office and required company locations in diverse environments
    6.4 Must be able to maintain a high level of consistent cognitive function to negotiate complex transactions with clients and prospects
    6.5 Must be able to tolerate normal office climatic conditions associated with daily activities and if in travel to remote locations
    6.6 Must be able to physically travel to remote locations, including, but not limited to, international and remote locations.

  • Senior Associate Scientist – Protein Engineer

    The purpose of the Senior Associate Scientist – Protein Engineer is to provide the execution of Protein analysis and characterization of novel Adeno-associated Virus capsids in addition to recombinant therapeutics genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report results to colleagues

    1. Scope
    1.1 Department Name: Research and Development
    1.2 Reports To: Senior Scientist R&D

    2. Principal Responsibilities and Accountabilities
    2.1 Design protein assays to solve complex questions and provide analysis on said assays
    2.2 Perform ELISA, IHC, Western blot, Immunofluorescence, and Immunoprecipitation
    2.3 Perform molecular biology techniques (Gibson Cloning, PCR, RT-PCR, qPCR, Restriction enzyme analysis, and preparing DNA libraries)
    2.4 Design of cloning strategies for plasmid vector construction
    2.5 Tissue Culture of Non-adherent and adherent cells
    2.6 Transfections including liposome-mediated, electroporation and viral
    2.7 In vitro transcription/translation-based protein expression and small-scale purification
    2.8 Communication of work, plans and progress using written and verbal communication in small groups and large meetings

    3. Specific Skills and Abilities
    3.1 Must be self-motivated, organized, capable of working independently as well as in a collaborative/group environment to collaborate with manufacturing process development staff on experimental studies
    3.2 Strong analytical and computer skills are required
    3.3 Sound understanding of statistical experimental design and analysis such as design of experiments is a plus
    3.4 Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus
    3.5 Should possess strong oral and written communication skills
    3.6 Good judgment and innovation to achieve a solution within standard practices and procedures
    3.7 Experience with global teams, especially Spanish speaking, a plus

    4. Latitude
    4.1 This position requires the ability to act independently and to take initiative with minimal supervision
    4.2 This role has no spend authority except through request process

    5. Minimum Qualifications
    5.1 B.S, degree in Microbiology, Molecular Biology, Cell Biology, Biology or related field
    5.2 3-5 years of industry experience or equivalence based on level of degree completion
    5.3 Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment
    5.4 Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required
    5.5 Must possess strong workload planning skills, organization, attention to detail, and follow through
    5.6 Must have excellent written and verbal communication skills. Ability to prioritize and multi-task concurrent project demands
    5.7 Strong computer skills in Microsoft Office required e.g. Word, Excel, and PowerPoint.

    6. Physical and Cognitive Demands
    6.1 Must be able to hear, see and speak
    6.2 Dexterity to manage presentations, work with equipment in demonstrations or advisement and to handle daily lab/office equipment
    6.3 Must be able to move about the office/lab and required company locations in diverse environments
    6.4 Must be able to maintain a high level of consistent cognitive function to negotiate complex transactions with clients and prospects
    6.5 Must be able to tolerate normal office climatic conditions associated with daily activities and if in travel to remote locations
    6.6 Must be able to physically travel to remote locations, including, but not limited to, international and remote locations.