Careers

Lead The Way In Gene Therapy With AskBio


AskBio was founded by gene therapy industry leaders, whose discoveries and AAV platform technology and applications form the foundation for how important gene therapies are effectively and safely delivered to millions of people who suffer from incurable conditions. One of AskBio’s founders, Dr. Jude Samulski, is considered the father of AAV gene therapy and is the inventor of over 280 patents and applications for AAV technology.

Today, AskBio is leading the way in gene therapy and we need exceptional researchers, scientists, analysts and clinicians to join us in our quest to change lives with groundbreaking gene therapies and manufacturing processes. When you join the AskBio team:

  • You’ll be part of one of the most exciting gene therapy research and delivery companies in the world
  • Your work will contribute to the advancement of therapies and applications that are revolutionizing curable possibilities
  • You will have opportunities for significant growth with competitive pay and outstanding benefits
  • You will be a part of a collaborative culture that shares a genuine desire and belief to change the world

Driven To Bring Cures To Millions Across The World

AskBio and its gene therapy technology based on the discoveries of Dr. Jude Samulski drive the work of more than two-thirds of gene therapy companies worldwide. Dr. Samulski was the first to clone AAV which was the dawning of hope for millions suffering from devastating diseases.

Open Positions

Please review the following open positions and apply now to upload your resume.

  • Vice President, Human Resources

    Overview: The Vice President, Human Resources is responsible for leading strategy and execution of all aspects of the employee experience, including but not limited to talent acquisition, workforce planning, succession planning, total rewards inclusive of health and benefits, employee relations, and change management. Further, and in partnership with senior leadership, this role is responsible for contributing to all aspects of the company’s culture, inclusion and diversity, and organizational effectiveness.

    About Us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next VP of Human Resources to join the AskBio team!

    About the Role: 

    Overview: The Vice President, Human Resources is responsible for leading strategy and execution of all aspects of the employee experience, including but not limited to talent acquisition, workforce planning, succession planning, total rewards inclusive of health and benefits, employee relations, and change management. Further, and in partnership with senior leadership, this role is responsible for contributing to all aspects of the company’s culture, inclusion and diversity, and organizational effectiveness.

    Position Summary:

    The Vice President, Human Resources develops and executes the human resource strategy in support of the overall business plan and employee experience. S/he provides insightful and credible leadership to the CEO, Senior Team, VPs and the Board of Directors and other stakeholders.   Provide leadership direction and solutions that are creative and forward-looking, demonstrating a strong presence across all functions of the HR profession. This leadership role also carries with it personal and corporate responsibility to build and sustain a respectful, stimulating, engaging and fun workplace.

    Responsibilities and Accountabilities: 

    Lead and Direct:

    • Provide strategic leadership and pragmatic guidance to the HR function by having accountability for talent acquisition, employee relations, career development, succession planning, retention, leadership development, HR compliance and compensation and benefits.
    • Optimize HR impact for the business through streamlined processes and use of technology that foster a positive and dynamic employee experience.
    • Direct talent acquisition for fast growing business including counsel on organizational design, job design and workforce planning/ forecasting.
    • Coach and mentor all levels of talent so they may achieve their full potential and career development.
    • Advise the CEO and Senior Team on organizational plans, company policies, and legal issues.
    • Establish and implement HR efforts that effectively communicate and support Ask Bio’s overall business vision, mission and values, and strategic and operational initiatives.
    • Use and command of human capital data to further talent attraction, retention and engagement initiatives.
    • Develop and manage the annual budget for the department.
    • Manage HR compliance requirements. Manage exposure of the company and serve as primary contact for internal and external counsel and outside government agencies.
    • Guide managers and employees in resolving employee relations issues by providing effective conflict resolution and coaching.
    • Strong understanding of HR information systems and experience with 1-2 implementations (example: ATS, Payroll, LMS, Compensation)

    Key Leadership Competencies:

    • Innovative and Agile – Ability to innovate and approach situations in new ways. Thinks broadly and creatively, beyond immediate details and issues and conventional thinking, to encourage forward-thinking ideas and approaches. Anticipates crises and problems. Displays curiosity and a passion for learning.
    • Proactive – Seeks to proactively identify trends and opportunities impacting the organization. Has an outstanding analytical mind. Has a proven ability to prioritize and manage competing and sometimes conflicting priorities.
    • Thoughtful – Draw on wide-ranging sources of information and networks of relationships to develop and carryout complex business strategies and initiatives. Ability to succinctly communicate complex initiatives or issues.

    About You: 

    • Passion:
      • You love what you do professionally, and the impact HR can have in Ask Bio.
    • Education:
      • Bachelor’s degree required. Advanced degree preferred.

    Professional Experience:

    • Minimum 15 years of progressive HR experience with depth in several functional areas including talent acquisition, benefits, compensation, HRIS, employee relations and compliance.
    • Experience working in research environment and government contracting environment is a plus.
    • Proven track record of success in positions that required a strong mix of business skills, leadership abilities, strategic thinking, and sound judgment in driving organizational effectiveness is required.
    • Deep experience implementing overall HR best practices, including directing talent management and leading all aspects of culture, diversity, change management and organizational development, employee engagement, training approaches, and career pathways;
    • Thought partner to executive leadership teams;
    • Expertise in linking programs and strategies to organizational goals delivering high impact results.

    More About You: 

    • Authentic leader and manager with a collaborative and inclusive approach in assessing individual/organizational challenges, problem solving, and developing partnerships.
    • Thoughtful, energetic, and diplomatic change ambassador; an experienced professional in understanding organizational dynamics, guiding individuals and teams through complex and changing environments.
    • Facilitative style and approachable manager, strong advisor to the CEO and the Senior Team.
    • Excellent communication skills, both written and verbal, with the ability to represent Ask Bio both internally and externally across a wide range of stakeholders.
    • Exceptional coach and mentor; demonstrated experience in influencing and supporting senior leaders.

    AskLife:

    • We offer a competitive total rewards package.

    Are you our next great discovery?

    **Please note – AskBio does not provide sponsorship at this time.**

  • Associate Scientist, Analytical Development

    The purpose of the Associate Scientist, Analytical Development position is to support the development and qualification and execution of analytical assays for In-process analytics, Process Development and non-clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides analytical test methods development, qualification and validation support for future non-GMP drug product release.

    About Us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Associate Scientist Analytical Development to join the AskBio team!

    About the Role: 

    The purpose of the Associate Scientist position is to support the development and qualification and execution of analytical assays for In-process analytics, Process Development and non-clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides analytical test methods development, qualification and validation support for future non-GMP drug product release.

    Responsibilities and Accountabilities: 

    • Support the design, establish, and develop capillary electrophoresis (CE)-based viral separation and quantitation methods.
    • Develop ELISA-based Viral quantitation assays for impurities in viral AAV products.
    • Develop methods for biophysical protein analysis methods such as – DLS, aggregates and particulates in drug product.
    • Provide analytical testing support for Process Development, R&D and external CMO teams to assist in the development and analytical characterization of new therapeutic targets.
    • Support/execute qualification/validation of developed analytical methods and tech transfer the methods to partner CMO.
    • Author development reports, study protocols, SOPs and pre-validation reports.
    • Contribute to technical discussions and investigations within the analytical group and help support Process development and non-clinical manufacturing.
    • Detailed, organized, formal record keeping through lab notebooks.
    • Has excellent communication skills and works well in a small group work environment.

    About You: 

    • BS or MS in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 1-4 years’ experience.
    • Demonstrated experience in development of various analytical assays including CE, DLS, MFI, qPCR, ELISA, AUC, etc.
    • Proven ability to work in a fast-paced environment, meet deadlines, & prioritize work on multiple projects. Strong attention to detail with the ability to handle multiple responsibilities simultaneously.
    • Must be able to support generating high quality data for presentations and publications.
    • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About You: 

    • Must be self-motivated, organized, capable of working independently as well as follow directions in a collaborative/group environment.
    • Should possess strong oral and written communication skills.
    • Must exhibit strong troubleshooting skills with minimal supervision.
    • Good judgment and innovation to achieve a solution within standard practices and procedures.
    • Experience with global teams, especially Spanish speaking, a plus.
    • Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.
    • Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife:

    • We offer a competitive total rewards package.

    Are you our next great discovery?

    **Please note, AskBio does not provide sponsorship at this time**

  • Senior Scientist, Analytical Development

    The purpose of the Senior Scientist, Analytical Development position is to provide the designing, development, qualification and execution of analytical assays to support In-process analytics, Process Development and non-clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides analytical test methods development, qualification and validation support for future non-GMP drug product release.

    About Us:

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Senior Scientist, Analytical Development to join the AskBio team!

    About the Role: 

    The purpose of the Senior Scientist position is to provide the designing, development, qualification and execution of analytical assays to support In-process analytics, Process Development and non-clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides analytical test methods development, qualification and validation support for future non-GMP drug product release.

    Responsibilities and Accountabilities: 

    • Design, establish, and develop Viral Infectious titer assays including TCID50, Safety (rcAAV) and Potency assays
    • Develop qPCR/ddPCR and ELISA-based Viral quantitation assays for viral AAV products
    • Develop methods for protein analysis such as – SDS-PAGE, BCA, Western blots, RT-qPCR, etc.
    • Provide analytical testing support for Process Development, R&D and external CMO teams to assist in the development and analytical characterization of new therapeutic targets.
    • Design and coordinate/execute qualification/validation of developed analytical methods and tech transfer the methods to partner CMO.
    • Author development reports, study protocols, SOPs and pre-validation reports.
    • Evaluating CRO/CMO test results and writing summary reports of the results when needed.
    • Contribute to technical discussions and investigations within the analytical group and help support Process development and non-clinical manufacturing.
    • Bring in newer technologies for characterization of AAV drug products.
    • Detailed, organized, formal record keeping through lab notebooks.
    • Has excellent communication skills and works well in a small group work environment.

    About You: 

    • MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 3-6 years’ experience.
    • Demonstrated method development and qualification experience in viral safety, potency, viral infectious titer, qPCR/ddPCR, TCID50, etc.
    • Proven ability to work in a fast-paced environment, meet deadlines, & prioritize work on multiple projects. Strong attention to detail with the ability to handle multiple responsibilities simultaneously.
    • Must be able to generate high quality data for presentations and publications.
    • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About You: 

    • Must be self-motivated, organized, capable of working independently as well as in a collaborative/group environment to collaborate with manufacturing process development staff on experimental studies
    • Prior industry experience in gene therapy is strongly desired
    • Should possess strong oral and written communication skills
    • Must exhibit strong analytical method development skills with use of statistics and design of experiments highly desirable.
    • Good judgment and innovation to achieve a solution within standard practices and procedures.
    • Experience with global teams, especially Spanish speaking, a plus.
    • Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.
    • Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife:

    • We offer a competitive total rewards package.

    Are you our next great discovery?

    **Please note, AskBio does not provide sponsorship at this time**

  • Clinical Research Associate (CRA)

    The purpose of the Clinical Research Associate (CRA) is to provide oversight and risk management for clinical research activity. The CRA will verify the rights and well-being of human subjects are protected, that trial data is accurate, complete and verifiable and the trial is conducted in compliance with applicable regulatory requirements.

    About Us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next CLINICAL RESEARCH ASSOCIATE to join the AskBio team!

    About the Role: 

    The purpose of the Clinical Research Associate (CRA) is to provide oversight and risk management for clinical research activity. The CRA will verify the rights and well-being of human subjects are protected, that trial data is accurate, complete and verifiable and the trial is conducted in compliance with applicable regulatory requirements.

    Responsibilities and Accountabilities: 

    Serve as core team member with support and supervision on project teams.

    • Conduct feasibility assessments of planned clinical trials.
    • Conduct activities as outlined below to ensure clinical trials are adequately monitored (as stated in ICH guidelines).
      • Act as the main line of communication between AskBio and the investigator.
      • Verify that the investigator has adequate qualifications and resources and remain adequate throughout the trial period, that facilities, including laboratories, equipment, and staff, are adequate to safely and properly conduct the trial and remain adequate throughout the trial period.
    • Verify, for the investigational product(s):
      • That storage times and conditions are acceptable, and that supplies are sufficient throughout the trial.
      • That the investigational product(s) are supplied only to subjects who are eligible to receive it and at the protocol specified dose(s).
      • That subjects are provided with necessary instruction on properly using, handling, storing, and returning the investigational product(s).
      • That the receipt, use, and return of the investigational product(s) at the trial sites are controlled and documented adequately.
      • That the disposition of unused investigational product(s) at the trial sites complies with applicable regulatory requirement(s) and is in accordance with the sponsor.
    • Verify that the investigator follows the approved protocol and all approved amendment(s), if any.
    • Verify that written informed consent was obtained before each subject’s participation in the trial.
    • Ensure that the investigator receives the current Investigator’s Brochure, all documents, and all trial supplies needed to conduct the trial properly and to comply with the applicable regulatory requirement(s).
    • Ensure that the investigator and the investigator’s trial staff are adequately informed about the trial.
    • Verify that the investigator and the investigator’s trial staff are performing the specified trial functions, in accordance with the protocol and any other written agreement between AskBio and the investigator/institution and have not delegated these functions to unauthorized individuals.
    • Verify that the investigator is enrolling only eligible subjects.
    • Report the subject recruitment rate.
    • Verify that source documents and other trial records are accurate, complete, kept up-to-date and maintained.
    • Verify that the investigator provides all the required reports, notifications, applications, and submissions, and that these documents are accurate, complete, timely, legible, dated, and identify the trial.
    • Check the accuracy and completeness of the CRF entries, source documents and other trial-related records against each other. The monitor specifically should verify that:
      • The data required by the protocol are reported accurately on the CRFs and are consistent with the source documents.
      • Any dose and/or therapy modifications are well documented for each of the trial subjects.
      • Adverse events, concomitant medications and intercurrent illnesses are reported in accordance with the protocol on the CRFs.
      • Visits that the subjects fail to make, tests that are not conducted, and examinations that are not performed are clearly reported as such on the CRFs.
      • All withdrawals and dropouts of enrolled subjects from the trial are reported and explained on the CRFs.
    • Inform the investigator of any CRF entry error, omission, or illegibility. Ensure that appropriate corrections, additions, or deletions are made, dated, explained (if necessary), and initialed by the investigator or by a member of the investigator’s trial staff who is authorized to initial CRF changes for the investigator. This authorization should be documented.
    • Determine whether all adverse events (AEs) are appropriately reported within the time periods required by GCP, the protocol, the IRB/IEC, AskBio, and the applicable regulatory requirement(s).
    • Determine whether the investigator is maintaining the essential documents as required by applicable regulations.
    • Communicate deviations from the protocol, SOPs, GCP, and the applicable regulatory requirements to the investigator and taking appropriate action designed to prevent recurrence of the detected deviations.
    • Support the development of a subject recruitment plans.
    • Evaluates the quality and integrity of site practices – escalating quality issues as appropriate.
    • Qualify and oversee external vendors that provide clinical research services.
    • Responsible for partnering and contributing to the Target Product Profile (TPP), evidence generation strategies, and for the project per stage gate process.
    • Attend all team meetings and serves as a single point of contact for communication between the project team and investigational sites.
    • Assess, communicate and manage the risks associated with the clinical development plan.
    • Communicates progress and milestone status to leadership, R&D partners and others.
    • Organize multi-disciplinary team and engage necessary disciplines to address project goals and objectives.
    • Works cross functionally to assess project risks, product safety and efficacy on projects.
    • Surveys the literature to identify and compare competitive product performance and safety risks.
    • Provides input and reviews for study protocols and reports from clinical studies.
    • Identifies external labs (academic, CRO), as needed, to execute clinical studies. Initiates contract and audits, if necessary.
    • Participates in reviews and provides recommendations for business development opportunities.
    • Perform other activities as assigned by the Chief Medical Officer and senior management.

    About You: 

    • Bachelor’s degree in a health care or relevant scientific field.
    • Interest and capacity to learn and understand program science.
    • One to three years of clinical research experience in pharma, biotech or contract research organization.
    • Demonstrated ability to work with different personalities and styles efficiently and prioritize activities based on ambiguous or quickly changing information and environments is critical.
    • Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.
    • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About You: 

    • Must be self-motivated, organized, capable of working independently as well as in a collaborative/group environment.
    • Should possess strong oral and written communication skills.
    • Good judgment and innovation to achieve a solution within standard practices and procedures.
    • Knowledge of project management tools, including, but not limited to, MS Project, Excel, PowerPoint, Word, etc..
    • Solid understanding of international regulations and good clinical practices related to clinical research.
    • Experience with gene therapies is preferred.
    • Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.
    • Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife:

    • We offer a competitive total rewards package.

    Are you our next great discovery?

    **Please note, AskBio does not provide sponsorship at this time.**

     

  • Director of Patient Advocacy

    The purpose of the Director of Patient Advocacy is to lead AskBio’s engagement with patients and patient advocacy organizations to ensure the patient voice is incorporated into product development at AskBio. This key role serves as a liaison among patients, families, advocates, the community, and AskBio in the development of outreach, the communication of issues, and the administration of compassionate use programs.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Director of Patient Advocacy to join the AskBio team!

    About the role: 

    The purpose of the Director of Patient Advocacy is to lead AskBio’s engagement with patients and patient advocacy organizations to ensure the patient voice is incorporated into product development at AskBio.  This key role serves as a liaison among patients, families, advocates, the community, and AskBio in the development of outreach, the communication of issues, and the administration of compassionate use programs.

    Responsibilities and Accountabilities

    • Serve as primary contact for patients/families/patient advocates on behalf of AskBio.
    • Identifies key advocacy groups supporting indications for which AskBio is developing therapies.
    • Develops and cultivates relationships with patient advocacy organizations consistent with the phase of development of AskBio clinical programs.
    • Works with the Project Lead and Clinical Operations to develop patient engagement strategies.
    • Collaborates with Social Media Coordinator and external marketing agencies to develop patient/advocate awareness of AskBio clinical programs.
    • Represents AskBio at patient advocacy meetings and conferences.
    • Creates and oversees systems to track communications and initiatives for patient advocates.
    • Develops and manages a Frequently Asked Questions database for patients and advocates.
    • Monitors PatientsFirst@AskBio.com e-mailbox.
    • Communicates progress and milestone status to leadership, R&D partners and others.
    • Manages investments and activities in support of patient outreach within the annual budget for Patient Advocacy.
    • Recruits and organizes Patient Advisory Boards, as needed, in support of clinical programs.
    • Perform other activities as assigned by the Chief Medical Officer and senior management.
    • Works to cultivate a culture of appreciation for Patients as Partners within Askbio.

    About you: 

    Bachelor’s degree in a health care or relevant scientific field.  Nursing or MSW degree preferred.

    Interest and capacity to learn and understand program science.  Gene therapy experience and/or neuromuscular disease experience highly desirable.

    At least 3 years of experience in pharma or biotech, or at least 5 years of experience in a hospital, advocacy group, or contract research organization.

    Experience with and understanding of the drug development process.

    Demonstrated ability to work with different personalities and styles efficiently and prioritize activities based on ambiguous or quickly changing information and environments is critical.

    Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.

    Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About you: 

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

    **Please note, AskBio does not provide sponsorship at this time**

  • Analytical Scientist

    The purpose of the Analytical Scientist position is to provide the planning, development, qualification and execution of analytical assays to support internal Research & Development, Process Development and non- clinical recombinant Adeno-associated virus (rAAV) vector manufacturing. This individual provides bioanalytical test methods development, qualification and validation.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Analytical Scientist to join the AskBio team!

    About the role: 

    The Analytical Scientist will provide analytical testing support for R&D and Process Development teams to assist in the development and analytical characterization of new capsids, therapeutic cassettes and improved manufacturing process steps.

    Responsibilities and Accountabilities

    • Develop and optimize bioanalytical test methods for rAAV gene therapy products intended for non-clinical and clinical applications.
    • Work closely with our partners for qualification and validation of analytical methods.
    • Author development reports, study protocols, SOPs and pre-validation reports.
    • Evaluating CRO/CMO test results and writing summary reports of the results when needed.
    • Identify basic technical issues, out-of-specifications results, instrument malfunctions and methodology problems, and participate in investigations.
    • Develop strategies to transfer these methods when needed to our partners or collaborators.
    • Detailed, organized, formal record keeping through lab notebooks.

    About you: 

    MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at
    least 1-3 years’ experience.

    Demonstrated experience in analytical techniques such as: PCR, sequencing, qPCR, SDSPAGE, HPLC, ddPCR, cell-based assays, ELISA, SEC, etc.

    Experience with mammalian cell culture techniques.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required in addition excellent interpersonal skill.

    Ability to multitask among multiple projects and teams and work independently in a fast paced, highly interactive environment.

    Demonstrated independence in experimental design, execution, data analysis, statistical analysis and troubleshooting are required.

    Attention to detail with excellent organizational and record keeping skills is a requirement.

    Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

    More About you: 

    Knowledge of or direct experience with rAAV vectors is a plus.

    Knowledge of FDA and EMA cGMP industry standards for analytical development and method validation a plus.

    Experience with writing regulatory documents or working in cGMP USP/EP environments would be considered a plus.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Associate Scientist Downstream Process Development

    The Associate Scientist- Downstream Process Development position provides support for execution of experiments designed to optimize recombinant adeno-associated virus downstream processing and purification for gene therapy applications. This role requires knowledge and a desire to learn principles of chemical engineering, biology, biochemistry, and related chemistries, preferably in chromatography, centrifugation and filtration design principles.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Associate Scientist Downstream Process Development to join the AskBio team!

    About the role: 

    The Associate Scientist- Downstream Process Development position provides support for execution of experiments designed to optimize recombinant adeno-associated virus downstream processing and purification for gene therapy applications. This role requires knowledge and a desire to learn principles of chemical engineering, biology, biochemistry, and related chemistries, preferably in chromatography, centrifugation and filtration design principles.

    Responsibilities and Accountabilities

    • Assist in the development of robust, efficient, scalable purification strategies for improving downstream process performance in collaboration with fellow scientists, collaborators, and upper management.
    • Communicate and collaborate across functional areas such as upstream process development, analytical development, manufacturing and R&D.
    • Conduct experiments and analyses as part of a variety of research and development activities, e.g., small-scale studies, scale up studies, technology transfer and process development.
    • Evaluate and summarize the experimental results, develop and test hypotheses to improve understanding of downstream purification strategies, yield, purity, and recovery.
    • Prepare internally reviewed technical reports.
    • Provide team support through preparation of solutions, lab cleanliness, and maintaining inventory or necessary supplies.

    About you: 

    BS or MS degree in a biological or engineering discipline (Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent).

    Experience in laboratory research, and a desire to continue in a laboratory-focused roll.

    Minimum 1-3 years of experience in laboratory research required, preferably in recombinant protein/biomolecule purification development, technology transfer and/or bioprocess manufacturing.

    Experience with filtration and chromatography.

    A good understanding of protein chemistry, protein analytics, and bioprocess technology is required.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

    More About you: 

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Sound understanding of statistical experimental design and analysis such as design of experiments is a plus.

    Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus.

    Experience with global teams, especially Spanish speaking, a plus.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Molecular Biology Scientist

    The purpose of the Molecular Biology Scientist position is to provide the execution of molecular biology techniques for the generation of novel Adeno-associated virus capsids in addition to recombinant therapeutic genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report the results to colleagues.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Molecular Biology Scientist to join the AskBio team!

    About the role: 

    The purpose of the Molecular Biology Scientist position is to provide the execution of molecular biology techniques for the generation of novel Adeno-associated virus capsids in addition to recombinant therapeutic genome cassette design and optimization for gene therapy applications. This position requires the design and execution of experiments and the ability to evaluate and report the results to colleagues.

    Responsibilities and Accountabilities

    • Provide leadership role in building and optimizing the design of AAV gene therapy constructs.
    • Responsible for hands-on experimental design, execution, data analysis and reports for AAV vector core pipeline research and development programs.
    • Develop molecular assays to characterize AAV genome integrity, identity, vector variants, residual DNA quantification, as well as in-vitro potency to support product development and manufacturing of gene therapy products.
    • Identification and implementation of operational improvements and novel technologies to improve AAV vector expression and key quality attributes.
    • Participate in project related teams and other internal/external collaborations.
    • Prepare and review technical reports and SOPs to support CMC regulatory activities.
    • In collaboration with Gene Therapy Technical Operations Leadership, develop strategic and operational vision for the organization.
    • Select, develop, and evaluate personnel to ensure the efficient operation of the function and represent the department internally/externally.
    • Work seamlessly with cross functional stakeholders including Process Development, Analytical Development and Translational Research to help advance the AAV vector production portfolio.
    • Ensure the development of robust, well-characterized, high quality and high yielding vector expression system.
    • Ensure that scientific and technical challenges are resolved in a timely manner.
    • Contribute to budget and goal planning.
    • Contribute to a safe, efficient and effective environment with personal accountability.

    About you: 

    BS, MS, or PhD in Molecular and Cell Biology or related field.
    0-2 years of relevant experience with PhD.

    3-5 years of relevant experience with MS.

    5-10 years of relevant experience with BS.

    Knowledge of cGMP.

    Experience working in a laboratory setting.

    Knowledge of LIMS.

    Ability to work both independently and in a fast-paced team-oriented setting.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

    More About you: 

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?

  • Senior Scientist – Upstream Process Development Group Leader

    The purpose of the Senior Scientist Upstream Process Development Group Leader will lead the developing upstream (cell culture) processes for recombinant Adeno-associated viral (rAAV) vector gene therapies. This position manages and mentors a team of Associates and Scientists on upstream process development, scale-up, optimization, characterization, and transfer of projects while providing scientific expertise, guidance, and development opportunities.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Senior Scientist Upstream Process Development Group Leader to join the AskBio team!

    About the role: 

    The purpose of the Senior Scientist Upstream Process Development Group Leader will lead the developing upstream (cell culture) processes for recombinant Adeno-associated viral (rAAV) vector gene therapies. This position manages and mentors a team of Associates and Scientists on upstream process development, scale-up, optimization, characterization, and transfer of projects while providing scientific expertise, guidance, and development opportunities.

    Responsibilities and Accountabilities

    • Demonstrates innovative design, development, and execution of process development projects through literature review and scientific teamwork.
    • Assess and interpret experimental data using DOE and statistical techniques.
    • Develops robust, scalable, transferable processes for upstream production of rAAV clinical gene therapy vectors.
    • Serve as a Subject Matter Expert (SME) for the development of robust, high performing upstream processes with emphasis on transferability to cGMP manufacturing and supports regulatory filings.
    • Leads both from the bench and from the desk (designing studies, analyzing data, preparing reports and documents).
    • Training new or current team members and delegating tasks appropriately.
    • Provide input on the acquisition of capital equipment.
    • Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience.
    • Writes study reports, process characterization reports, transfer documents, and regulatory documents.
    • Authors manuscripts and presents results at scientific meetings.
    • Builds a culture that embraces continuous learning, innovation while encouraging team members to expand their technical skills and deepen their gene therapy expertise.

     

    About you: 

    • MS or PhD (Chemical engineering, Bioengineering, Biology, Biochemistry, Virology, or related field) with 5+ years’ experience or MS with 8+ years’ experience, in process development of large molecule or cellular therapies.
    • Knowledge and experience with media development, fed-batch, perfusion etc methodologies.
    • Knowledge and working experience with cell culture process development in mammalian cells, process scale-up, bioreactor design and optimization, and transfection.
    • Knowledge and experience with process characterization and transfer is essential. Expertise in DOE and statistical analysis of data is essential.
    • Knowledge and experience with ambr systems.
    • Knowledge of viral gene therapy (AAV vectors preferred); background in protein and/or viral engineering
      Experience leading teams of scientists and associate scientists.
    • Understanding and knowledge of regulatory requirements for biologic products.
    • Strong organizational, analytical and problem-solving skills.
    • Demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings and collaborative interactions.
    • Responsible for maintaining up-to-date knowledge of regulatory requirements and quality standards related to area of development.
    • Ability to work both independently and in a fast-paced team-oriented setting.
    • Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required.

     

    More About you: 

    • Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.
    • Experience in regulatory IND filing and working knowledge of US/EU CLD requirements is highly desirable.
    • Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.
    • Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife:
    We offer a competitive total rewards package.

    Are you our next great discovery?

  • Cell Line Engineering Scientist

    The Cell Line Engineering Scientist will be to investigate cellular and molecular mechanisms for optimal recombinant Adeno-associated virus vector production. This position offers the opportunity to impact a growing portfolio of gene therapy programs in a fast-paced and innovative research environment.

    About us: 

    When AskBio’s scientific founder, Dr. Jude Samulski, discovered how the Adeno-Associated Virus (AAV) could be safely used to deliver corrected genes to cells with genetic defects, it propelled one of the most exciting and inspiring fields in medical research today. Now the foundation for an entire industry, it also inspired the development of a world-leading gene therapy platform that includes the Pro10TM cell line, an extensive capsid library, and new methods for lowering the cost of delivery.

    We know gene therapy is a highly complex business. But seeing the impact that gene therapy can have on patients suffering from incurable diseases fuels a never-ending passion to continually advance AAV gene therapy technology. We embrace the work that companies like Pfizer/Bamboo, Novartis/AveXis, and Roche/Spark are doing to advance gene therapy development as we all share a common goal: erase genetic disease.

    We are a company on the forefront of the industry, guided by the vision and unparalleled expertise of Dr. Samulski, the founder of AAV gene therapy. We invite all researchers, advocacy groups, patients and their families to join us on this mission to advance promising gene therapies and to change the face of health care.

    We are excited for our next Cell Line Engineering Scientist to join the AskBio team!

    About the role: 

    The Cell Line Engineering Scientist will be to investigate cellular and molecular mechanisms for optimal recombinant Adeno-associated virus vector production. This position offers the opportunity to impact a growing portfolio of gene therapy programs in a fast-paced and innovative research environment.

    Responsibilities and Accountabilities

    • Lead, design and execute cell line development, clone screening, selection and stability determination for rAAV producer/stable cell lines.
    • Design and develop novel ways of integrating and controlling gene expression of viral genes in stable cell lines.
    • Support early stage discovery efforts for lead candidate identification.
    • Implement high throughput and cutting-edge cell line development technologies to optimize platforms and shorten cycle time.
    • Train and manage team members and delegating tasks appropriately.
    • Provide input on the acquisition of capital equipment.
    • Assist in the generation of project and cost proposals, timelines, and work plans by applying scientific knowledge and project management experience.
    • Maintain a current awareness of scientific literature and actively applies new concepts and technologies as appropriate.

    About you: 

    MS or Ph.D. in Biological Sciences specializing in Cell Biology, Molecular Biology, Biochemistry, Virology, Chemical engineering or Biomedical Engineering with a minimum of 5-7 years’ experience in an industrial/research laboratory developing mammalian cell lines.

    MS or PhD in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 1-3 years’ experience.

    Excellent aseptic skills, experience with vector engineering, high-throughput gene expression technology and cell line engineering is a must.

    Experience in developing novel molecular and analytical tools for use during cell line development is a must.

    Proficient in a broad range of cell and molecular biology techniques including cloning (eg. Gibson and Golden Gate Assembly) and gene editing technologies such as CRISPR/Cas9.

    In-depth knowledge and extensive hands-on experience in mammalian cell line engineering using gene editing/KD approaches (CRISPR, Meganuclease and si/shRNA). Experience with CRISPR knock-in is strongly preferred.

    Experience with cell characterization technologies including GRO_Seq, DNA_Seq, qPCR, Western blot, ELISA, etc.

    Hands on experience with FAC-Sorting and Flow cytometry assay development.  Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment.

    Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) will be required in addition excellent interpersonal skill.

    More About you: 

    Hands on knowledge of DOE, JMP, FlowJo and GraphPad statistical software for use in design of technology development studies in a highly desirable.

    Experience in regulatory IND filing and working knowledge of US/EU CLD requirements is highly desirable.

    Must have a passport and are able to physically travel to remote locations, including, but not limited to, international and remote locations.

    Must be able to tolerate normal office climatic conditions associated with daily activities.

    AskLife: We offer a competitive total rewards package. Are you our next great discovery?